Unless I'm missing the setting, it is not possible to edit the crop region globally.
Example:
I'm setting up 100's of interior elevations on Construction Document sheets.
I have to go through each individual view, activate it, then select the crop region and override the setting (line weight in my case).
After about 10 of them, it become very tedious and time consuming.
Suggestion?
Make a global setting, similar to every other override involving line work.
Doing so will allow you to do it once and only have to change/modify the regions associated with plans, etc
OR
Not as good of a solution...Allow regions to be editable outside of an active viewport.
Allowing the user to select multiple views on a sheet and override them all at once VS Overriding them individually.
