Kudos to the both of you for this interesting thread!
I thought I'll add a link to a thread I started over the holidays.
While the main subject is T-Spline performance, one of the really limiting factors for mesh work even quad meshes is the fact that currently you cannot convert meshes into b-reps with more than 10k faces.
However, in the thread @jeff_strater mentions that at some point in time Fusion 360 will include mesh modeling. I am looking forward to that!
With tools such as 3DSmax and Maya AD should have plenty of experience with hadling larger meshes and modeling tools for meshes. If they rethink tools and worflows as they are doing with Fusion 360 it will be very interesting and should provide even more of the integration we are looking for between free-form surface and CAD modeling.