When accessing an instance of an family hosting nested families, its no problem to access the instance parameters of the nested family instances (via Revit API or Dynamo).
But SetParameterValues (dynamo) or SetValue (API) on an instance parameter of a nested family always results in message that paramater is read-only.
Parameter should be modifiable or in short "get rid of readonly flag", as long as the parameter are instance parameters, not associated with a parameter of the hosting family already.
This would enable to change the values of instance parameters of different instances of same family type to different values.
Note: Would users of Revit UI enable to change instance parameters of this type of families in schedules as well.