polyRemesh and polyRetopo are amazing tools particularly for hard surface modeling. It makes the usage of booleans a lot more acceptable and drastically helps speed up workflow for complex shapes with rounded cutouts. However, it is not perfect.
1. It does not handle cylinders particularly well. Straight edges along the length often bend become more diagonal.
2. It often creates spiraling edge loops which create further problems when smoothing, selecting and optimizing.
3. Could use more options to tweak retopology such as being able to draw "Retopo Guides" on the mesh using existing vertices to help guide the flow of retopology.
Hope to see you roll out more updates to this feature as it is incredibly handy.