So you are using a mouse (not a Wacom pen?) and your system/monitor specs are good. Are you able to recall what it is specifically you were doing in the UV Editor prior to the mouse cursor becoming offset? I wouldn't imagine this to be scene specific.
In the Maya Preferences, under the Display Category there is a checkbox at the bottom called Render OpenGL surfaces at full resolution. What is that set to? Is it on? (If it's on, you could try unchecking it then restarting Maya. If I remember correctly this will take Maya on Mac out of highDPI mode. Then you could try and see if the issue presents itself again).
I looked in our backlog for issues related to offset mouse cursors. I'll go over the reproduction steps for them in Maya 2023.3 (the version you are using from the attached picture above) and see if older issues that should have been fixed are resurfacing.
If possible could you get us a video or reproduction steps of it occurring on your side and upload it here to us?