If you haven't already - first download the latest driver from 3DConnexion.com and install it.
I haven't checked in the past couple of weeks if there is a newer driver released - but in the latest driver I have installed about a month ago there is an issue that 3DConnexion is aware of and will be fixed in next driver (if it hasn't already been fixed).
In Windows (I don't know about Mac) there is a small black and white cube in the lower right corner of the system tray to make changes.
Right clicking on the cube you can Calibrate.
Double clicking the cube brings up the 3D Connexion Control Panel.
But here is the issue - trying to set to Fusion focus the control panel might disappear behind Fusion and might not be set to Fusion as the active app.
Restore-down the Fusion window so that you can see Fusion and 3DConnextion control panel side-by-side.
Now click on Fusion and then go to the 3DConnexion control panel to set it up.
I prefer to change the Zoom/Pan behavior so that Pan Up/Down matches motion similar to Pan Left/Right.
You now be good to go.