@ethanA7E82 - a few recommendations:
First, you have way too many profiles in this loft. You can probably get very close to this mesh with 1/8 to even 1/10 of the number of profiles. That loft has 57 profiles in it. You can hardly even rotate the view with the time Fusion spends just painting the labels:

second, each profile is made of of separate curves. This is what really causes the point mapping to get confused.

If you go back and re-fit those splines (yes, I know that is a lot of work), you can come out with a much better loft result. Re-fitting those using Fit Curve to Mesh Section is really just two clicks - start and end point with the type set to spline. I noticed that some of the mesh sections are not complete, and then it's a bit more work to get the spline, but it is still not that many points. In this example, I took just one section, and replaced about 20 profiles with 4, each with only one spline in it, This completely gets rid of the wrinkles in the surface:

because each profile has only one curve, so there are no midpoints to map. And even though I was not very careful, the result matches the mesh pretty well. You could do much better pretty easily.

so the moral of the story is: lots fewer profiles, and one curve per profile.
Jeff Strater
Engineering Director