Can Different Page Setups Be Setup to Include/Exclude Layers?

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Is it possible to create different page setups that will print certain layers? When we submit our drawings we send them without item numbers for our products and without specific manufacturing instructions that only our shop needs to see. Once we receive the drawings back and can start production we print our drawings out with those layers now turned on for the shop. A current as-built copy of the shop drawings are sent back to the client with those layers turned back off.
I would like to try to take out the human error of "forgetting to turn the layers on/off" and have different page setups created ("11x17-Client" & "11x17-Shop") that would handle it by simply selecting the appropriate page setup.
Any way this can be accomplished without setting up multiple layouts with vpfreeze controls?
If it's not possible is there a way to create a warning message at the plot/publish stage to notify the user if those layers need to be on/off?
Just trying to eliminate mental reminders... We've got too many "mental" users here, including myself.