When I leave at the end of the day I exit all my app's and restart. Then the next morning "usually" I'm logging into a fresh clean system. So yes, I do restart before running although it's 12 hours before I log back in.
I just rebooted to try to start clean and an assembly I opened early this morning in a couple minutes took 25 minutes to open. I looked at the events log and see a lot of errors within the first 5-10 minutes of powering up. I also looked at the drain on my system when it was trying to open the drawing. This is the system and doesn't seem to be struggling.

And not sure how good anyone is at analyzing event viewer logs but this is the summary and detailed info (stripped out the XML info to reduce size of text).
___________________________________________________________
Error 12/16/2020 10:23:14 AM User Device Registration 304 None
Error 12/16/2020 10:23:14 AM User Device Registration 307 None
Warning 12/16/2020 10:20:17 AM DistributedCOM 10016 None
Warning 12/16/2020 10:20:17 AM DistributedCOM 10016 None
Error 12/16/2020 10:19:52 AM DistributedCOM 10010 None
Error 12/16/2020 10:19:26 AM User Device Registration 304 None
Error 12/16/2020 10:19:26 AM User Device Registration 307 None
Warning 12/16/2020 10:19:26 AM LSA (LsaSrv) 6038 None
Warning 12/16/2020 10:18:42 AM DistributedCOM 10016 None
Error 12/16/2020 10:18:42 AM Kernel-EventTracing 2 Session
Warning 12/16/2020 10:18:34 AM DistributedCOM 10016 None
Warning 12/16/2020 10:18:34 AM DistributedCOM 10016 None
Error 12/16/2020 10:18:28 AM DistributedCOM 10010 None
Warning 12/16/2020 10:18:27 AM User Device Registration 360 None
Error 12/16/2020 10:18:15 AM User Device Registration 304 None
Error 12/16/2020 10:18:15 AM User Device Registration 307 None
Error 12/16/2020 10:17:45 AM VSS 8193 None
Error 12/16/2020 10:17:45 AM VSS 13 None
Error 12/16/2020 10:17:45 AM VSS 8193 None
Error 12/16/2020 10:17:45 AM VSS 13 None
Error 12/16/2020 10:17:45 AM Service Control Manager 7043 None
Error 12/16/2020 10:16:57 AM User Device Registration 304 None
Error 12/16/2020 10:16:57 AM User Device Registration 307 None
Error 12/16/2020 10:13:07 AM Perflib 1020 None
Warning 12/16/2020 10:06:55 AM DistributedCOM 10016 NoneLog Name:
___________________________________________________________
Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:23:14 AM
Event ID: 304
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed at join phase.
Exit code: Unknown HResult Error code: 0x801c001d
Server error:
Tenant type: undefined
Registration type: undefined
Debug Output:
joinMode: Join
drsInstance: undefined
registrationType: undefined
tenantType: undefined
tenantId: undefined
configLocation: undefined
errorPhase: discover
adalCorrelationId: 116a7d70-ae90-426e-83f3-47a7f1f584de
adalLog:
undefined
adalResponseCode: 0x0
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:23:14 AM
Event ID: 307
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed. Failed to lookup the registration service information from Active Directory. Exit code: Unknown HResult Error code: 0x801c001d. See http://go.microsoft.com/fwlink/?LinkId=623042
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:20:17 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
The application-specific permission settings do not grant Local Launch permission for the COM Server application with CLSID
Windows.SecurityCenter.WscBrokerManager
and APPID
Unavailable
to the user NT AUTHORITY\SYSTEM SID (S-1-5-18) from address LocalHost (Using LRPC) running in the application container Unavailable SID (Unavailable). This security permission can be modified using the Component Services administrative tool.
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:20:17 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
The application-specific permission settings do not grant Local Launch permission for the COM Server application with CLSID
Windows.SecurityCenter.SecurityAppBroker
and APPID
Unavailable
to the user NT AUTHORITY\SYSTEM SID (S-1-5-18) from address LocalHost (Using LRPC) running in the application container Unavailable SID (Unavailable). This security permission can be modified using the Component Services administrative tool.
Event Xml:
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:19:52 AM
Event ID: 10010
Task Category: None
Level: Error
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The server Microsoft.SkypeApp_15.66.77.0_x86__kzf8qxf38zg5c!App.AppXtwmqn4em5r5dpafgj4t4yyxgjfe0hr50.mca did not register with DCOM within the required timeout.
Event Xml:
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:19:26 AM
Event ID: 304
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed at join phase.
Exit code: Unknown HResult Error code: 0x801c001d
Server error:
Tenant type: undefined
Registration type: undefined
Debug Output:
joinMode: Join
drsInstance: undefined
registrationType: undefined
tenantType: undefined
tenantId: undefined
configLocation: undefined
errorPhase: discover
adalCorrelationId: 0fd6fc9b-2b68-4e2b-b726-ec9f0a74acf9
adalLog:
undefined
adalResponseCode: 0x0
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:19:26 AM
Event ID: 307
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed. Failed to lookup the registration service information from Active Directory. Exit code: Unknown HResult Error code: 0x801c001d. See http://go.microsoft.com/fwlink/?LinkId=623042
Event Xml:
Log Name: System
Source: LsaSrv
Date: 12/16/2020 10:19:26 AM
Event ID: 6038
Task Category: None
Level: Warning
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
Microsoft Windows Server has detected that NTLM authentication is presently being used between clients and this server. This event occurs once per boot of the server on the first time a client uses NTLM with this server.
NTLM is a weaker authentication mechanism. Please check:
Which applications are using NTLM authentication?
Are there configuration issues preventing the use of stronger authentication such as Kerberos authentication?
If NTLM must be supported, is Extended Protection configured?
Details on how to complete these checks can be found at http://go.microsoft.com/fwlink/?LinkId=225699.
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:18:42 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The application-specific permission settings do not grant Local Launch permission for the COM Server application with CLSID
Windows.SecurityCenter.WscCloudBackupProvider
and APPID
Unavailable
to the user RND\sveix SID (S-1-5-21-4263432456-2811916617-2856734872-1650) from address LocalHost (Using LRPC) running in the application container Unavailable SID (Unavailable). This security permission can be modified using the Component Services administrative tool.
Log Name: Microsoft-Windows-Kernel-EventTracing/Admin
Source: Microsoft-Windows-Kernel-EventTracing
Date: 12/16/2020 10:18:42 AM
Event ID: 2
Task Category: Session
Level: Error
Keywords: Session
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
Session "Cloud Files Diagnostic Event Listener" failed to start with the following error: 0xC0000022
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:18:34 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The application-specific permission settings do not grant Local Activation permission for the COM Server application with CLSID
{2593F8B9-4EAF-457C-B68A-50F6B8EA6B54}
and APPID
{15C20B67-12E7-4BB6-92BB-7AFF07997402}
to the user RND\sveix SID (S-1-5-21-4263432456-2811916617-2856734872-1650) from address LocalHost (Using LRPC) running in the application container Unavailable SID (Unavailable). This security permission can be modified using the Component Services administrative tool.
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:18:34 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The application-specific permission settings do not grant Local Activation permission for the COM Server application with CLSID
{2593F8B9-4EAF-457C-B68A-50F6B8EA6B54}
and APPID
{15C20B67-12E7-4BB6-92BB-7AFF07997402}
to the user RND\sveix SID (S-1-5-21-4263432456-2811916617-2856734872-1650) from address LocalHost (Using LRPC) running in the application container Unavailable SID (Unavailable). This security permission can be modified using the Component Services administrative tool.
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:18:28 AM
Event ID: 10010
Task Category: None
Level: Error
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The server Microsoft.SkypeApp_15.66.77.0_x86__kzf8qxf38zg5c!App.AppXtwmqn4em5r5dpafgj4t4yyxgjfe0hr50.mca did not register with DCOM within the required timeout.
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:18:27 AM
Event ID: 360
Task Category: None
Level: Warning
Keywords:
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
Windows Hello for Business provisioning will not be launched.
Device is AAD joined ( AADJ or DJ++ 😞 Not Tested
User has logged on with AAD credentials: No
Windows Hello for Business policy is enabled: Not Tested
Windows Hello for Business post-logon provisioning is enabled: Not Tested
Local computer meets Windows hello for business hardware requirements: Not Tested
User is not connected to the machine via Remote Desktop: Yes
User certificate for on premise auth policy is enabled: Not Tested
Machine is governed by none policy.
See https://go.microsoft.com/fwlink/?linkid=832647 for more details.
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:18:15 AM
Event ID: 304
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed at join phase.
Exit code: Unknown HResult Error code: 0x801c001d
Server error:
Tenant type: undefined
Registration type: undefined
Debug Output:
joinMode: Join
drsInstance: undefined
registrationType: undefined
tenantType: undefined
tenantId: undefined
configLocation: undefined
errorPhase: discover
adalCorrelationId: 47de26e8-89cd-499e-b933-6f9e1399dd58
adalLog:
undefined
adalResponseCode: 0x0
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:18:15 AM
Event ID: 307
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed. Failed to lookup the registration service information from Active Directory. Exit code: Unknown HResult Error code: 0x801c001d. See http://go.microsoft.com/fwlink/?LinkId=623042
Log Name: Application
Source: VSS
Date: 12/16/2020 10:17:45 AM
Event ID: 8193
Task Category: None
Level: Error
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
Volume Shadow Copy Service error: Unexpected error calling routine CoCreateInstance. hr = 0x8007045b, A system shutdown is in progress.
Log Name: Application
Source: VSS
Date: 12/16/2020 10:17:45 AM
Event ID: 13
Task Category: None
Level: Error
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
Volume Shadow Copy Service information: The COM Server with CLSID {4e14fba2-2e22-11d1-9964-00c04fbbb345} and name CEventSystem cannot be started. [0x8007045b, A system shutdown is in progress.
]
Log Name: Application
Source: VSS
Date: 12/16/2020 10:17:45 AM
Event ID: 8193
Task Category: None
Level: Error
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
Volume Shadow Copy Service error: Unexpected error calling routine CoCreateInstance. hr = 0x8007045b, A system shutdown is in progress.
.
Log Name: Application
Source: VSS
Date: 12/16/2020 10:17:45 AM
Event ID: 13
Task Category: None
Level: Error
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
Volume Shadow Copy Service information: The COM Server with CLSID {4e14fba2-2e22-11d1-9964-00c04fbbb345} and name CEventSystem cannot be started. [0x8007045b, A system shutdown is in progress.
]
Log Name: System
Source: Service Control Manager
Date: 12/16/2020 10:17:45 AM
Event ID: 7043
Task Category: None
Level: Error
Keywords: Classic
User: N/A
Computer: WS-SVEIX.RND.local
Description:
The AsusUpdateCheck service did not shut down properly after receiving a preshutdown control.
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:16:57 AM
Event ID: 304
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed at join phase.
Exit code: Unknown HResult Error code: 0x801c001d
Server error:
Tenant type: undefined
Registration type: undefined
Debug Output:
joinMode: Join
drsInstance: undefined
registrationType: undefined
tenantType: undefined
tenantId: undefined
configLocation: undefined
errorPhase: discover
adalCorrelationId: c8912deb-58a5-4ca6-aab0-8175a359a4fe
adalLog:
undefined
adalResponseCode: 0x0
Log Name: Microsoft-Windows-User Device Registration/Admin
Source: Microsoft-Windows-User Device Registration
Date: 12/16/2020 10:16:57 AM
Event ID: 307
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
Automatic registration failed. Failed to lookup the registration service information from Active Directory. Exit code: Unknown HResult Error code: 0x801c001d. See http://go.microsoft.com/fwlink/?LinkId=623042
Log Name: Application
Source: Microsoft-Windows-Perflib
Date: 12/16/2020 10:13:07 AM
Event ID: 1020
Task Category: None
Level: Error
Keywords:
User: SYSTEM
Computer: WS-SVEIX.RND.local
Description:
The required buffer size is greater than the buffer size passed to the Collect function of the "C:\Windows\System32\perfts.dll" Extensible Counter DLL for the "LSM" service. The given buffer size was 31744 and the required size was 42976.
Log Name: System
Source: Microsoft-Windows-DistributedCOM
Date: 12/16/2020 10:06:55 AM
Event ID: 10016
Task Category: None
Level: Warning
Keywords: Classic
User: RND\sveix
Computer: WS-SVEIX.RND.local
Description:
The machine-default permission settings do not grant Local Activation permission for the COM Server application with CLSID
{C2F03A33-21F5-47FA-B4BB-156362A2F239}
and APPID
{316CDED5-E4AE-4B15-9113-7055D84DCC97}
to the user RND\sveix SID (S-1-5-21-4263432456-2811916617-2856734872-1650) from address LocalHost (Using LRPC) running in the application container Microsoft.Windows.ShellExperienceHost_10.0.18362.1171_neutral_neutral_cw5n1h2txyewy SID (S-1-15-2-155514346-2573954481-755741238-1654018636-1233331829-3075935687-2861478708). This security permission can be modified using the Component Services administrative tool.