The short answer is that this SVG will run poorly. There are 26000 lines in the single sketch. Many of which are nearly zero length segments. This also results in about equal points at 26000. Meaning you have a massive sketch with a ton of objects. Its possible that you could clean this up in Fusion, but its sketching engine really isn't designed for cleaning up 2D line work and sketches like this. (it lacks simplification tools and those that can combine large quantities of objects and purge null or nearly null segments/points - many in this sketch are lines at .001" long)
Disabling profiles will help, but i'll be honest, this design needs AutoCAD, not Fusion 360 to clean up first. Even when or if you get the sketch working, that many lines and points in CAM will likely cause contour selection problems and overall finish on a CNC router may be poor. I can try to look at it in AutoCAD and see if it can be cleaned up in a bit.
Ryan Bales
Fusion 360 Product Support