In the modern CAM and CNC world, there are a couple things in particular that those new to the field would do very well in understanding. That is Work Offsets and Tool Offsets.
Work Offsets: On paper; write directions around your city block, from where you are standing. They make sense, don't they? Now, move 40 miles/km away. Do they make sense any more? Not so much, since they are relative to where you were standing when you wrote them down. So, you need to give another movement direction, a Work Offset, so to speak. That would be your G54 to G59 in CNC world (assuming a modern control). So, the part is programmed to itself, and then you tell the machine where the part is, much like the directions around the city block.
Same sort of idea for the Tool Offsets. Each tool is programmed to go to it's specific depth, whether that is a 10mm deep hole, or a 20mm deep profile contour pass. Then, using Tool Offsets in the machine control (the CNC, not Fusion) you can tell the control where the end of the tool is in relationship to it's home position.
That's basically it, in a nutshell.
For wonderful bedside reading material, I'd recommend this guy: http://www.cnccookbook.com/
The guy has more information then you would ever need, but a lot of it is explained in such a manner that makes a lot of sense.
I'd also recommend the youtube videos by NY CNC, a job shop that uses Fusion, you will find good tidbits there as well https://www.youtube.com/user/saunixcomp
Seth Madore
Owner, Liberty Machine, Inc.
Good. Fast. Cheap. Pick two.