FlexSim is currently a Windows-only software (see FlexSim's system requirements). In order to run FlexSim on your Mac, you will need to either dual-boot into Windows (using Bootcamp), or virtualize a Windows installation on top of macOS (using Parallels, VMware, or some other virtualization solution).
Dual-booting usually results in better performance, especially for a graphically intensive program like FlexSim. It allows the operating system to have direct access to the hardware.
With virtualization, your mileage may vary. Different software and hardware vendors, and drivers, support virtualization to greater and lesser degrees. You may find that FlexSim's performance is not as good when running on a virtualized system, or you may run into stability or other issues.
UPDATE: As mentioned in comments below, FlexSim works very well using the latest version of Parallels, even on Apple silicon like their new M1 chip.
There are currently no plans to support the Mac platform.
UPDATE - July 2022: FlexSim is actively exploring going multi-platform to support both macOS and Linux, in addition to Windows. There is not currently a timeline or estimated release date.
If anyone in our community can chime in with their experience with FlexSim on a Mac, or any tips to getting the most from virtualization, please add your voice to the comments below.