I made a point of reaching out to Autodesk on GPU settings multiple times and to multiple product teams.
Back in mid-April 2018, I couldn't even get Scott Crider (Senior Product Manager for AutoCAD Team) to return emails asking for his help with this. To boot, I've been asking the C3D Team for help since June 2018 and they didn't even bother to respond at all (before Tim joined this thread, of course, for which I am grateful, assuming something eventually comes from their participation here):
https://forums.autodesk.com/t5/civil-3d-forum/civil-3d-nvidia-quadro-settings/m-p/8065853/highlight/...

However, even after following their recommendations I still found C3D's performance to be utterly miserable.
My earlier Snagit GIF didn't even do this justice, as I noticed after the fact that Snagit's default capture frame rate was only 15 FPS, so what I posted previously was actually faster than what was really happening for me in CAD - I've adjusted that to be 30 FPS but am also now just going to use Camtasia to produce the full frame rate GIFs.
In these last few posts, I've now ignored Autodesk's recommendations and just look at the difference for yourself:

Selecting vertex-dense Polylines and Feature Lines still have a noticeable lag for single Object selection, but even that has improved from what it was before.
Separately, as @Anonymous (if not also others before them in this thread) aptly pointed out, there's still something going on with contextual tabs, as they have a noticeable lag behind the Properties palette... Despite the GPU settings changes, there is improvement using Full Without Focus over Full With Focus, but using Merged I can literally count to 3 or 4 out loud before it shows up.
Hey @TimYarris - It would be really great if the C3D team could document something useful for certified GPU hardware settings. I'm not even sure that I have the 'best' settings yet, having only gone against Autodesk's recommendations a couple of hours ago, but the difference is night and day. So anything more than the big fat nothing we have today would be awesome. Haha :beer:
Cheers