If this is a large file, then you may want to try adjusting your printer settings. When you go to plot, next to your printer name choose 'Properties', then 'Custom Properties'. In the 'Advanced' tab, choose the option 'Avoid Out of Memory' instead of 'Maximum Performance'. Your computer will send the entire drawing to the plotter and the plotter my not have enough memory to hold the entire drawing. When you avoid out of memory, the drawing stays in your computer and sends it as it plots so that the plotter can handle large or mulitple plots.
Caryn