Either way is the last resort, because it's whatever works best. I will always go for the 2d first.
The oblique text styles and the +30 and -30 dimensions are part of my regular template file and are always there. On the keyboard that I use for most commands (sits next to my regular keyboard), there are already shortcut keys for DIMOBLIQUE and the view multiplier as well as the regular DIMALIGNED, etc.. It may be simply because I'm set up for this, but the 2d is faster for me.
Even drawing the cube you posted, I had to get used to which way to set the UCS so the dims are not backwards, flip the one at the front left for right, etc.. And I don't usually go to 3d to draw a cube. I will draw in AutoCAD in isometric until I think it would be faster with 3d, then I whip out a 3d model, FLATSHOT and I'm back in my drawing, often with only a part of what I need in isometric (the difficult to draw part). So 2d is easier for me.
I was just trying to help the OP, Randall, not to get in a discussion about whether you should use shape files for text, whether to draw on Layer 0, or whether to use the dashboard, ribbons, or neither. Dimensioning isometric drawings, and even drawing many of them, is both faster and easier in 2d for me.
Thanks,
-- Dunn