Hi @vgrover,
We have seen some compatibility issues with the 3D SpaceMouse in previous versions of Moldflow. One thing you can try is to ensure that your driver is up-to-date. Another possible remedy is to add the System Variable as indicated in this article on the Autodesk Knowledge Network.
It is hard to replicate this issue as it doesn't seem to affect every PC and SpaceMouse configuration, though the development team here at Autodesk is aware of the compatibility issues and are working towards a solution for future Moldflow releases.
Kind regards,
Justin Bonfili

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Justin Bonfili
Customer Technical Success