I always have to guess whether I need to use the horizontal or the vertical constrain when sketching, since it's relative to the global coordinate system.
After using other 3D softwares I've relied on that the vertical and horizontal constrains were placed relative to the orientation of the view.
I don't find it efficient having to always keep track of the global coordination system when sketching, since I often rotate or orient parts and drawings.
It just bugs me a lot every time I select the "wrong" option even though it's "right" choice for my exact view.
Or even rework those constrains entirely. When sketching, I don't care to which coordinate system those points are vertical or horizontal, they just have to be in-line with each other.