Not the perfect solution for all situations, but in many cases measuring from a midpoint to another midpoint and using the Delta measurements gives the desired information:

Edge midpoints are available to the Measure tool without any special options (keep selection priority on the default Faces and Edges). Expanding the Delta measurements and then selecting any of the three shows all of them in the graphics area, color coded to match the coordinate system indicator. The limitation, though, is this only works for measurements that are aligned with the coordinate system.
Sam B
Inventor Pro 2022.2.1 | Windows 10 Home 21H2
