With a week's time, I had to remove FOUR installations of Revit 2020 that were upgraded to 2020.2.7, all by way of the Autodesk Update App, because the application failed to open after the update was applied. After the first incident, I had to make sure that it wasn't a mistake, so after I cleaned it up--using Autodesk's own manual removal documentation--I reinstalled Revit 2020 and then systematically updated it, patch at a time, still using the Update app; with each major patch (2.2, 2.3, etc.), I would stop updating and open the application. However, as soon as I applied 2.7, Revit 2020 wouldn't even open, not even after 20 minutes.
Once again, I manually removed Revit 2020, reinstalled it, then applied all patches up to 2.6, but NOT 2.7. Shortly after that first incident, three other users applied the 2.7 update, each of which resulted in Revit 2020 failing to open. At that point, I issued a company-wide directive to users of Revit 2020 to NOT install the 2.7 patch until Autodesk comes up with a solution.
Autodesk documentation indicates that patches cannot be removed individually; the entire application must be removed. However, I note that starting with Revit 2022, it appears that individual patches CAN be removed.