Yes I did try the ISO post processor with moderate success. It created files without error messages. But let me lay this out with some more info.
A) This MultiCam M series machine (50x100 inch table) has only ever run on .plt files created by ArtCam (Pro, I believe). A little googling revealed that the .plt files are supposed to be HPGL files so I wanted to start experimenting with them. But on account of the error I used the ISO post and named the files with a .cnc suffix. The jobserver on the router computer picked up these files just fine and the machine loaded them without trouble.
B) I had a problem with the machine losing Home 1 (the starting corner of the material) while running the first file. Everything seemed to be going fine when about 80% of the way through the job it moved to a position almost 2 feet away from my piece of material! It took me a while of loading new files to realize the problem was that home was no longer where I had set it. At first I thought there was only 1 home jump during that job but after assembling the pieces I realized that a few other elements were perhaps a half inch off of where they should have been so there may have been other jumps.
C) I cut 3 more pieces of material with minor tweaks to each of them so I loaded several different .cnc files into the machine. 2 of them seemed to cut perfectly but the last one cut about a 1/4" off in the x dimension (the big jump earlier was I think entirely in the y axis). It seemed like this shift must have happened right at the very beginning because the entire thing was correct with itself, just off about a 1/4". I had just set the Home 1 immediately before running the job so I know it was "correct" with regard to the piece of material.
D) Can a cut file actually change the machine home? I wasn't aware that this could happen. I would like to do more experimenting but it's awfully time consuming and so far hasn't inspired confidence in Fusion 360 in the eyes of the machine owner.
E) The owner of this machine was kind of freaked out by the difference in the way the machine moved compared to the files from ArtCam. I was particularly impressed by the slow downs in the "corners". I wasn't expecting it to return to Home 1, pause and then put the tool away after the job (this has a 4 tool changer) and the owner almost jumped when he saw it moving to unload the tool since it's motion was so different than normal. I guess he thought it was going to crash into the table. (But all the motion for picking up and dropping off tools should be programmed into the table hardware so I wouldn't expect that to be any different.)
F) Having the CAM integrated was so much nicer than my old way of bouncing between at least one CAD package and the ArtCam software to iron out fixes with material on the table.
The first ISO (.CNC) file that I had the homing problems with is attached.