A million different ways. What is your CNC machine?
Get the notion of "million dollars of equipment" or $200k router out of your head. You'd be surprised at how little it takes to be profitable and efficient. You could likely get into a router with tool changer for under 80k.
It all depends on what your projected shop rate should be, how many other tasks you should be completing etc. My opinion, find a way to get the machine to run for a loooong time. Who cares if each part takes 2 min longer. With the time you have free, you DON'T go take a nap or watch tv. You run another machine, you program your next job, you prep parts for the current machine. Don't look at it as "this machine needs to make $xx an hour". It's more "the shop" needs to be making $xx an hour.
If you aren't going to be standing in front of it (the machine) to tend it, there is a lot more room to move on pricing. I have 2 machines in my shop, a new Mori DuraVertical that see a LOT of high tolerance short running parts, and an old '82 Matsuura that sees several long running jobs. If I make half the amount per hour on the Matsuura, I don't care, because it's just running unattended and it's paid for. Steady income stream that pays my wage and a little extra with no appreciable tooling costs (aluminum work)
Seth Madore
Owner, Liberty Machine, Inc.
Good. Fast. Cheap. Pick two.