Do you mean that you want to input inches per second when you are programming (see it in the CAM strategy wizards/windows) or do you mean that you just want to be able to set the inches per minute correctly when programming and have the post processor convert the feedrate to inches per second? I don't know that the former will be possible, but the latter is doable. I'll have to test it out to be sure (if that is what you are after), but for the most part you can apply math within the post processor to facilitate conversions like that. I have gone to the extent of doing math on tool numbers to generate workspace coordinate numbers. What you can do in the post processor is often limited only by how imaginitive you get with the variables available.
If it were me, I'd be looking to program in inches per minute, but get the output in inches per second. For the most part, any interaction you have with others will be on an inches per minute or mm/minute basis, so there is some disadvantage to thinking in terms of inches per second. It may take a short adjustment period, but it would probably be worth adapting. I did the same to learn to work in millimeters in CAD/CAM, but I do all of my actual shop measurements in inches. It took some time to get used to working in metric, but I find that math easier to deal with and the conversions are second nature now. Even still, old habits die hard and my use of the metric system ends in the digital world. It would be a much smaller adjustment to learn programming in in/min vs in/sec, so you should be able to get used to it quickly.