Something I find works very well is to chop up your reference drawing, and overlay the different views on the correct planes.

Do each panel as one operation.

But if you really want to refine your surface, a program like PolyCad (it's free!) will give better results.
I would also redraw using B-spline curves (control point spline) instead of your fit-point splines. And as Peter said, follow the best practices for working with splines.
But as Fusion has limited surface modelling abilities, it might not ultimately give you what you are looking for..
PolyCad will also let you import reference images, as well as refine your surface like the below.
https://youtu.be/FDdwXXSKQ9g