I have been experimenting with some of the Meshmixer capabilities in anticipation of introducing them into Fusion. That work is underway now. The team has been spending considerable effort to ensure good performance with large mesh files.
Where can the mesh come from? Mesh can come from converted CAD data, reality capture or polygonal modelers like Mudbox. Currently the output will always be a mesh which can be visualized, 3d printed or machined. Part of the long term goals of the Fusion Mesh project include extracting lines and surfaces for a more standard reverse engineering approach. We are also working on methods of automating the process of mesh to CAD conversion.
Here is an example of a "mashup" between CAD generated data and scan data.
The "Make Solid" command is the basis of creating these geometric "mashups". Here I have a scan from a Next Generation scanner and a new base created as a solid in Fusion and converted to mesh.

I repaired areas of the scanned mesh with the Erase and Fill command which will repair holes while evaluting the surrounding mesh to flow the patch. I also cut the scanned base off and extruded the remaining latch so that it extended into the CAD base.

I combined the two meshes and used the Make Solid command. I didn't need to attach the two meshes. They only had to intersect each other as the command envelops the mesh with voxels which define a closed region. Now there is one integrated mesh which is perfectly watertight and ready to print. Finally I used the Hollow command to hollow the interior.

The purpose of this experiment was to describe a workflow that can incorporate both mesh and CAD data. In some cases the mesh may not satisfy manufacturing criteria but there is a lot of power in using this strategy for prototyping and custom designs.
Let us know what you think.