Some Edges/seams are essential to defining form. That said, in some circumstances, Fusion will do a good job approximating geometry when a Face or Edge is deleted, but the geometry will shift- a little or a lot. This may be exploited on occasion to remove noise. You may find some operations- such as Fillet -fail in the presence of an Edge, even if centrally located as a seam- another valid reason to spend time removing them.
While there are reasons for concern, appearance of the finished part need not be if the transition was modeled smoothly. I like to test parts by switching to the Render workspace and rotating the light source and messing with the exposure levels to place reflections across the area in question- something greatly aided by the application of a reflective Appearance, such as Polished Aluminum or Plastics. Editing an Appearance, you can manually maximize reflectivity. Often performing an In-Canvas Render isn't even necessary- but when things are smooth, I'll run one.
When absolutely necessary to have no seam- and there is no other recourse -I'll recreate the surface in the Sculpt workspace using the extant Body as a form to Pull Points to, Match edges, etc.
