I don't own a 3D printer but the consensus here on this forum has been that geometry does not have to be combine in order to be 3D printed. For the most part the slicer software will take care of this.
My experience has been that the "Save to STL" function just does not do a very good job of creating the STL file, ending up with one that has lots and lots of errors that are detected by the slicer, or at least by Meshmixer. I did a bunch of testing (prior to buying my own printer), trying to fix things with Meshmixer and/or slicers, and then uploading them to 3D printing services, only to have those services say that the file is not printable.
So my approach has been to Save To STL, see what Meshmixer thinks of it, and then go back to the Fusion file and try to make changes that will result in no, or at least fewer, errors in the created STL file. Even then, there have been STL errors which, when "fixed" by Meshmixer, ends up creating a horribly disfigured model.
So my best approach has been to try to SOLID-ify the model in Fusion via the Combine/Join tool so that each part that I want to send out for printing is a single Body. So far that approach has been pretty successful and I've actually been able to make some prints.
With that in mind for much of the geometry in your designs it is better to create instances of geometry buy copy/pasting or patterning. Rather than say pattern bodies. In such a detailed design that can grow a design very quickly. That is particularly true for a design with an enabled timeline.
Timeline designs are approximately 3 times the size than DM designs.
I am indeed creating instances of and patterning Components. I am not patterning Bodies.
As for having the timeline enabled, that has been absolutely crucial in creating my overall design. There is no way that I could have developed this and done the necessary editing to it if it had been done in Direct Modelling mode, especially since this is the first significantly complex design that I've done. Everything prior to this was just small projects. Fusion 360 is the first 3D modelling software that I've ever used. So I'm definitely still in learning mode.