Hi @mathews.225,
Welcome to the forum. You are seeing this error message because we can not launch the application you have selected as the 3D print application. The Mac OS is very restrictive on launching applications from within another application. In some cases it will only allow an application to launch another application, if the application to be launched, has been opened once explicitly by the user. It is a security precaution. I am sorry the error message was not clearer. In order to fix the problem, go to the application selected in the 3D print dialog, in my case below "Print Studio" and launch the application and then close it. If you do not know where the application is installed, you can use the MacOS Spotlight tool to find it. Let me know if this solves your issue.

Thank you,
Kris Berg
Senior Software Architect - Autodesk