We've run into tolerance issues with parts designed in F350 more than a few times.
It's certainly possible to keep track of them by hand, but it'd be fantastic to just be able to specify that a length is 10± 0.05mm (or 10-0.1mm or 10+0.1mm or‥), and then have those be variables that we can change later, and numbers placed in manufacturing drawings, and things that we can use in interference testing (if two walls are non-interfering but their tolerances cause them to overlap then that should be flagged as the alternative is that two parts that are meant to have a sliding fit end up having an interference fit, or vice-versa)