Drawing setup structure will depend on the size of the project and its requirements.... but generally, for medium to large projects where organization structure start making a real impact:
- Do your design in design drawings. Here you can have design oriented styles (e.g. corridor code set style with the links on), profile views that are not split up, section views organized in draft style, have all sorts of important design notes, guide lines, etc. Have multiple design drawings for different things if necessary (e.g. grading only drawing, since grading is notoriously unstable)
- Use data shortcuts to put it all together into a presentation drawing, using presentation styles. This drawing doesn't have any of the design notes, sketches, etc. Profiles are split up for sheet views, and section views are layed out based on sheet templates. If you prefer to have one sheet drawing per layout then you might want to setup different presentation drawings depending on its purpose (road sheets, pipe sheets, etc).
- Xref the presentation drawing into individual sheets, and add sheet specific labels there (e.g. road geometry labels for road drawing, pipe labels for pipe drawing, etc). Add viewport specific annotation on paper space of individual layouts.
Keep in mind the following goals to keep drawing handling speed fast and maintain high efficiency going back and forth between design updating and plotting 1) avoid flipping styles all the time 2) avoid having to freeze/unfreeze things, especially VP freezes and 3) keep the number of dynamic labels to a minimum on any given drawing because they are the #1 source of drawing slow down. Data shortcuts achieve all of that.
Where xrefs are handy, for design elements, is for letting you get away with doing less setups of dref'd parts. For instance, you can dref in the alignment, profile and corridor, setup some profile views and section views for sheets, then just xref this into individual sheet drawings so that if you have 10 road layouts you only have to do the setup once, not 10 times. And it forces you to stay consistent between sheets.
The TLDR version: Design DWG ----Dref----> Presentation DWG ----Xref----> Sheet DWG, and plot/etransmit with sheet set.