I remembered seeing this issue before and a quick forum search brought this up:
==============================================================
I just found this, but it may answer your question. This is a legacy item from AutoCad Release 14.
http://download.autodesk.com/ProdSupp/updates/td105129.htm#E10E11
Why are network paths removed from the support search path?
AutoCAD R14 will remove any invalid path from its Support File Search Path. This is designed behavior to insure that performance is not degraded when AutoCAD searches through all support paths that are listed. A path that becomes invalid during an AutoCAD session, such as when a network connection is lost, is still displayed in Preferences. This is because the path remains in the Windows registry even though AutoCAD cannot access it. Any invalid path is removed when you exit and restart AutoCAD. If you work in an environment where paths regularly become invalid, there are two methods you can use to quickly restore the Support File Search Path.
Method 1
Use the /s command line start-up switch to add the paths to the shortcut icon used to start AutoCAD. For example:
"C:\Program Files\AutoCAD R14\acad.exe" /s "C:\Program Files\AutoCAD R14\support";"C:\Program Files\AutoCAD R14\fonts";"C:\Program Files\AutoCAD R14\help";"C:\Program Files\AutoCAD R14\bonus\cadtools";M:\temp;\\myserver\searchpath
In this case, suppose either drive M or the Universal Naming Convention (UNC) path to a mapped drive to a server that is frequently unavailable. If the server is down and you start AutoCAD, \\myserver\searchpath is not added to the Support File Search Path. Restarting AutoCAD when the server is up restores the Support File Search Path automatically.
Method 2
Export a Profile with the required settings for the Support File Search Path (this creates an .ARG file). When you notice that some support paths have been removed in Preferences, start AutoCAD when the paths become available again, and then import the saved profile to restore the Support File Search Path.
FWIW
Regards,
DJ