Since standard Metric paper sizes are measured in Millimeters it would not make sense to setup a Layout with Meters as the paper size.
It seems some are assuming you mean the word "layout" as in paper space Layouts as AutoCAD uses the word. Is that right, or are you talking about laying out things like building or sitework dimensions?
If the latter, the drawing unit in AutoCAD can represent anything you want it to, from an angstrom to a parsec.