My most common mistake is making edits to drawings that are not in the active project. Quite frequently I work with more than one project, we split the machine down into smaller subprojects. If I edit the schematic in a not-active dwg, it doesn't drive thru to the layouts and so forth.
~maybe the project manager tree could show the drawings in the active project in a different style or color. (It does now bold the active project name, but inactive dwgs in the list look just like active ones). Say the active project dwgs are listed in italic, or red or something.
~what if the background color changed for dwg not in active project. Normally I work with the old black background. Suppose there was a choice for active (black) and flip to white background (white) for active. Of maybe the ribbon changes color or something.
~Commands could prompt "Current dwg not in active project, do you wish to continue?)