There is no direct way to assign a line style as "non-plot" in Revit. Are the guidelines part of the titleblock family? If not, I suggest you make them part of the family. If they are, in the Family Editor for the sheet, you can give the guidelines a Yes/No parameter (either Type or Instance, that is up to your preference) then assign this parameter to the lines' visibility settings. That way you can easily turn the lines off for plotting/printing and back on when adjusting the sheet in Revit.
Edit:
If you don't want to include the lines in the titleblock family, you can assign the lines to a new Subcategory, then hide that subcategory in the V/G menu by clicking on the + sign next to "Lines" then un-checking that new subcategory. But, similar to an instance parameter, you will need to do this on each sheet one-by-one, which is why a visibility parameter in the titleblock family is easier to work with for this situation.