No. Within the API documentation:
Document under the Creation namespace is a class, with the description: "The Document Creation object is used to create new instances of elements within the Autodesk Revit project."
Create() under the Document class of the DB namespace is a property, with the description: "An object that can be used to create new instances of Autodesk Revit API elements within a project."
Base on this, Creation.Document is used for creating objects/elements within Revit itself, while DB.Document.Create() is used to create new instances of API objects (aka code elements, not model elements).
I could be mistaken, so you could always test it to see what errors, if any, you get.