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I can't really determine what is actually happening with this issue but as best i can tell when I disable and re-enable the nucleus node it causes a massive slowdown in the UI and all operations in Maya, input text into fileds, playback, opening windows - everything except navigating the viewport is virtually unusable.
Restarting Maya has no affect. Maya remains in this hobbled state until I reboot the machine and everything goes back to normal, until I need to disable the nucleus again.
![Autodesk Design & Make Report](https://forums.autodesk.com/t5/image/serverpage/image-id/1350519iCB55845EBFC43016/image-size/large?v=v2&px=999" "Autodesk Design & Make Report")