yes it is.
You can find information about:
properties here:
https://knowledge.autodesk.com/search-result/caas/simplecontent/content/list-all-iproperties-and-how....
about subtypes here:
https://adndevblog.typepad.com/manufacturing/2013/01/inventor-document-sub-types.html
it will be only problem with project and status tab because there is no such property set they are only showed in project and status tabs but parent propertyset named "Design Tracking Properties" is much bigger :

so to accomplish that you can use simple loop like:

it will cleanup summary and remove all custom iproperties.
to clean project and status you need to do it like this:
prop_set = doc.PropertySets.Item("Design Tracking Properties")
prop_set.Item("name of property to clean up").Value=""
also when you have ipropert with date format then you need to set some date not to clean it up like here:
https://forums.autodesk.com/t5/inventor-ilogic-and-vb-net-forum/vba-change-quot-creation-date-quot-i...
so to sum this up here is the code wit only some samples of cleaning project and status tabs:
'"4D29B490-49B2-11D0-93C3-7E0706000000" - part
'"9C464203-9BAE-11D3-8BAD-0060B0CE6BB4" sheet metal
If ThisDoc.Document.SubType = "{4D29B490-49B2-11D0-93C3-7E0706000000}" Or ThisDoc.Document.SubType = "{9C464203-9BAE-11D3-8BAD-0060B0CE6BB4}" Then
Dim doc As PartDocument = ThisDoc.Document
Dim prop_set As PropertySet = doc.PropertySets.Item("Inventor Summary Information")
For i = 1 To prop_set.Count
prop_set.Item(i).Value=""
Next
prop_set = doc.PropertySets.Item("Inventor Document Summary Information")
For i = 1 To prop_set.Count
prop_set.Item(i).Value=""
Next
If doc.PropertySets.Item("Inventor User Defined Properties").Count > 0 Then
prop_set = doc.PropertySets.Item("Inventor User Defined Properties")
Dim count As Integer= prop_set.Count
For i =0 To count
Try
prop_set.Item(count-i).Delete
Catch
End Try
Next
End If
' project and status tabs properties clean up:
prop_set = doc.PropertySets.Item("Design Tracking Properties")
prop_set.Item("Project").Value = ""
prop_set.Item("Description").Value = ""
prop_set.Item("Part Number").Value = ""
prop_set.Item("Checked By").Value = ""
prop_set.Item("Date Checked").Value="01.01.0001"
End If
marcin.