I've gotten this problem also. A further error below is "Relationship was placed with respect to geometry that is no longer available."
In my case it was a problem with leaving broken constraints uncorrected because I replaced an iPart with a replacement regular part (with model states).
My workaround was to suppress all the broken constraints/relationships, THEN do the simplify command, and it should actually let you.
(The annoying part is that I could even see the simplified part in the workspace window, but I could not Accept it because there was no Accept button--only Cancel button).
@johnsonshiue, Please add an Accept button!
P.Eng. Mechanical Engineer
Dell Precision 5680 Laptop; Win11 Pro; 64GB RAM; i9-13900H CPU; Intel Iris Xe Graphics, NVIDIA RTX 3500 Ada Laptop GPU.
Vault Pro 2025.1 (30.1.63.0); Inventor Pro 2025.1.1 (241).