I've used Inventor Pro / Routed systems (which includes Tube/Pipe and Wiring/Harness functionality) for many years doing process plant design.
I would agree with @jhackney1972 on this one - I'd suggest for handrails, you're better off using Frame Generator, NOT Tube/Pipe. Tube & Pipe is optimized for internal flow routing. It wants to create flow routes from point A to B. This is not what handrails are all about. Tube & Pipe shines when you have process equipment connected from this flange to that flange, and you have to route through pipe racks and around equipment.
Handrails are connected to structure. I use Frame generator for both the structural and the handrail, ad they're connected. If you're talking about sending PIPE spool data out for CNC bending/forming, I've actually not done that. Most of the process plant work I've done is welded pipe, or small instrumentation tubing on skid packages.
FG is more than capable of both bending elements, and generating your C/L drawings, though I'll confess that sending out bending info for CNC bending is not something I do a ton of.
Todd
Product Design Collection (Inventor Pro, 3DSMax, HSMWorks)
Fusion 360 / Fusion Team