Performance on macOS Catalina is erratic.

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I am having an erratic performance issue running Fusion 360 on macOS Catalina (running on a 2020 MacBook Pro 16" with the 2.4GHz 8 core Intel Core i9 processor, 32GB of ram, and AMD Radeon 5500M Pro GPU). I've performed a clean install of macOS, as well as Fusion 360 (before reinstalling macOS using the bundled uninstaller).
The issue I'm having is that occasionally Fusion 360 will freeze with the macOS rainbow spinner (application not responding). While this happens, the CPU usage of the machine is nearly zero. I've tried disabling all of the graphics options which only results in the visuals looking poor.
The design I'm working on is somewhat complex, but it is handled fine on a seperate Windows machine AND on a Windows virtual machine on the same MacBook Pro I'm having issues with.