Hi @Anonymous,
Thanks for posting!
When you say shortcuts, do you mean the icons for the commands you have placed in the command ribbon (i.e. the icons above Sketch, Create, Modify, etc.)? Or are you more talking about the keyboard shortcuts?
Would you mind recording an Autodesk Screencast of the issue as it happens on your machine? It would be useful to see the picks and clicks that you are making.
Also, by any chance are you using a 3rd party application to remote desktop from a Windows based machine into a macOS based machine or vice versa? I know that there is an issue when trying to use the keyboard shortcuts if you are using Fusion like this, just because Windows keyboards do not have a "Command" key.
Also, are you using any peripheral devices such as a 3DConnexion product or a Wacom tablet? If so, does unplugging the peripheral device make the shortcuts work again? If you are using a peripheral device, it might also be worth checking with the manufacturer's website to ensure that you are using the most up to date drivers for the device.
I hope this helps! Thanks in advance for the information and please let me know if you have any questions or concerns - I am always happy to lend a hand!
Cheers,