I'm not the original poster, but I can confirm that for my system setting the given environment variable restores the pre-April UI scaling behavior of Fusion (a huge lifesaver for me).
I observed the following behavior with display scaling set to 125% in Windows:
With QT_ENABLE_HIGHDPI_SCALING set to 0, the HighDPIScaling preview feature ENABLED in fusion, and 'Override high DPI scaling behavior' UNCHECKED in Windows compatibility settings, the interface renders at 100% scale.
With QT_ENABLE_HIGHDPI_SCALING set to 0, the HighDPIScaling preview feature DISABLED in fusion, and 'Override high DPI scaling behavior' UNCHECKED in Windows compatibility settings, the interface renders enlarged and blurry.
With QT_ENABLE_HIGHDPI_SCALING set to 0, the HighDPIScaling preview feature DISABLED in fusion, and 'Override high DPI scaling behavior' CHECKED (Scaling performed by: Application) in Windows compatibility settings, the interface renders at 100% scale.
Tl;DR - Your suggestion makes the UI behave exactly as it did before the update.
I really appreciate that you're looking into this; it was driving me nuts all week!