Hi etfrench
I don't mean to be disagreeable but I don't think that there is any need for a restart. I went through the file and rectified the sketch warnings. Mostly they just needed the sketch plane redefined but sketch 20 had actually lost a plane I think. All I had to do was go back in the timeline, create a 'plane at angle' from the horizontal line on sketch 16. then 'redefine sketch plane' of sketch 20 to that plane. I then did the same as you, mirrored the spline etc. on sketch 20 and the loft that you were attempting then worked.
That was an interesting loft and not one I have considered before so thanks for your video. I think though that I understand why your loft didn't work. To put it simply, I think it is because you needed to close out the top profile of sketch 18 (in the original model). This allows for a profile to point loft as you did with four guide rails... as long as tangent chain is switched off.
When you select rail 1 in your video at 3:21, tangent chain is on which I found led to some problems, I don't think this is a problem in your sketch because you have no other tangent lines to chain. However when you select rail 2 on sketch 2 at 3:27, tangent chain is still on and I found with that line/spline in that my equivalent to your sketch 2 (sketch 18) would 'tangent chain' select and mess up the loft. I wonder if calling it 'tangent chain' is not a little misleading in this respect. I wonder if it just means 'select lines that form a profile' and are closed out effectively.
If I turn off tangent chain however, I can loft between the same (sketch 20) profile you used and the point at the end of the original spline on sketch 16. If is not a particularly smooth loft but it does work.
I would be really interested to hear your thoughts. I am really don't mean to lecture I am just trying to come to an understanding of how well I know Fusion 360. I have only just started posting here so I hope I am not offending anybody.