Hi,
I agree with practicality but most tolerances needed with hardware like nuts and bolts isn't that tight. Just pick
one and stick with it if you have both available. If its about which drill is easier to find most designers I know of
would simply design the hole to a Standard size unless there is a very good reason not to. The sort of Project
where you need ultra precision does exist but you are probably using much more precision tools than a normal
drill and probably making the actual hardware also. Drilling Angle stock doesn't sound too precision to me. If you
really need to go to 5 decimal places then you wouldn't be worried about a 4mm drill.
I understand that there are two common systems of Standards but as I said, mixing those Standards when you
don't have to is a BAD idea. I'd suggest redesigning the Project so that it uses ONE Standard (unless it is critical
like for Brain Surgery or Nuclear Weapons) and even then I would be very careful if I did mix things.
Good Luck with your Project.
Andrew