OK, so I first tried redoing the Tspline mesh body myself, but could not get the patch to work either, I guess the combination of the very elongated hole with almost sharp corners along with the 3D curvy geometry is just too much for the Patch tool. So then I tried using the Fill Hole in the Sculpt environment, but the results probably are not what you want, although now that I think about it, likely can then use Edit Form to move back into a kind of shape that looking for. So I ended up creating a patch via extruding the sketch I used to cut the 3D curve into the body, then did a Boundry Fill to make a solid body, and finally used the variable fillet option in the Fillet tool to make a decent looking end I guess (not sure exactly what you're going for though).


I've attached the .f3d file. Let me know if you have questions about anything, including the alternative method I really didn't try of using Sculpt fill hole then Edit form to get back into right shape.
Good luck!
Jesse