My Spyder blows up good. I can't open it manually (python spyderlib\spyder.py), by debugging an add-in, nor by editing an add-in. I've also deleted any .spyder* folder I could find.
I'm on macOS Sierra 10.12.6 and:
print (sys.version)
3.5.3 (v3.5.3:1880cb95a742, Jan 16 2017, 08:49:46)
[GCC 4.2.1 (Apple Inc. build 5666) (dot 3)]
print (sys.path)
['/Applications/Fusion360.app/Contents/Libraries/Neutron/Spyder', '/Applications/Fusion360.app/Contents/MacOS', '/Applications/Fusion360.app/Contents/Frameworks/Python.framework/Versions/Current/lib/python3.5/site-packages', '/Applications/Fusion360.app/Contents/Frameworks/Python.framework/Versions/Current/lib/python35.zip', '/Applications/Fusion360.app/Contents/Frameworks/Python.framework/Versions/Current/lib/python3.5', '/Applications/Fusion360.app/Contents/Frameworks/Python.framework/Versions/Current/lib/python3.5/plat-darwin', '/Applications/Fusion360.app/Contents/Frameworks/Python.framework/Versions/Current/lib/python3.5/lib-dynload', '/Applications/Fusion360.app/Contents/Libraries/Neutron/', '/Applications/Fusion360.app/Contents/Libraries/Neutron/nspylib', '/Applications/Fusion360.app/Contents/Api/Python/packages', '/Applications/Fusion360.app/Contents/Frameworks/PYLIB_PYPI', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/Autorun/', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/Samples/', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/ProgramData/', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/AppData/', '/Users/edwin.wise/Library/Containers/com.autodesk.mas.fusion360/Data/Library/Application Support/Autodesk/Autodesk Fusion 360/MyScripts/ManuallyInstalled/']