I've had a lot of issues with lofting but one that keeps cropping up is that it'll often generate nonsensical results.
Case in point - consider lofting between two very symmetric profiles.
One would expect the loft to preserve the symmetries but instead it does something like this
I get that it can be hard to match but in a case like this, it's just a matter of recognizing that both planes are parallel, projecting one onto the other, and finding the nearest points.
It'd be great to be able to do things like this without adding a lot of rails and generally doing more work.