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No issues here in Win10Pro. Maybe you need to start over and skip migrating your old content this time (and skip any add-ons) https://knowledge.autodesk.com/support/autocad/learn-explore/caas/sfdcarticles/sfdcarticles/How-to-r...
Then install the 2022.1.2 Update: ABOUT command will confirm what you have installed. If not, get it from your Autodesk Account Page here https://manage.autodesk.com/cep/#products-services/updates
Restart your PC afterwards.
If you re still using your R2018 PC, you might need to also Set GFXDX12 variable to 0 (that's a zero) then restart AutoCAD/LT2022: reverting to DirectX11 fixes similar problems for most users.
It would appear you also have keyboard issues perhaps?
Files disappearing is an IT issue or file management issue, or an AutoCAD profile switch/change?
HTH