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"...but it undoes the layout, and I lose one of them. How do I set this up, for one, and once it is setup, is there any way I can lock their location on auto-hide, so I don't accidentally mess it up?"
What you are describing is called the Workspace: the arrangement of interface elements on the screen. In addition to the previous suggestion (LockUI), I would add that it is good practice to name your workspace (WSSave) and re-save it whenever you make a change. The Workspace is saved as part of the CUI file that is loaded as "main" in your AutoCAD profile. Most workspace changes are best made through the drawing editor interface, but some can be done more easily in the CUI editor.
It is also good practice to make an export of your Profile, as a backup, particularly if you customize anything that can be modified with the Options command. Be sure to include the exported profile (ARG file) and your customized CUIx file in any periodic system backup so that you can use them to recover relatively quickly from a computer problem that would require a re-install of AutoCAD.