Is it VMware Fusion or Parallels Desktop VM? Or maybe Virtual Box?
Do you talk about macOS VM or about Windows VM?
If you are trying to launch AutoCAD for Mac inside VM, then I'm afraid, it is not possible.
If you are about AutoCAD for Windows inside Windows VM, then it should run properly with default settings on VMware and Parallels, I have both and AutoCAD for Windows works fine (better with Parallels Desktop).