Hi Bárbara,

1. Audit has found 462 errors in your drawing:

Total errors found 462 fixed 462
Erased 0 objects

But even after fixing those errors I as not able to save as PDF the 2nd and 4th Layouts in AutoCAD 2017 and in AutoCAD 2016 for Mac.

At the same time I was able to save to PDF those Layouts in AutoCAD 2018 for Mac and even without fixing errors in your drawing with AUDIT command.

Then I went further and have found that the case of the issue was in gradient hatch, which is visible in the 2nd and 4th Layouts. After I changed the type of the hatch to Solid (I assigned it red color in your drawing and attached this drawing to my post), I was able to save to PDF the 2nd and 4th Layouts in 2017 and in 2016 versions.

Maxim